Caffeine Consumption in Teenagers: Effects on Sleep, Reward Processing, and Risk-Taking After Reduced Sleep Duration
Descrizione riassuntiva dello studio
Teenagers often do not get enough sleep. Due to maturation-related changes, the biologically optimal sleep window does not align with early school start times, leading to sleep deprivation. To cope with the resulting daytime fatigue, some turn to caffeine. It is unclear what effects caffeine has on subsequent nighttime sleep under these conditions. Additionally, it is largely unexplored whether and how the two factors 'sleep deprivation' and 'caffeine' separately, but also in interaction, influence adolescents' risk behavior and their sensitivity to reward. We aim to systematically investigate this in this project.
(BASEC)
Intervento studiato
Each participant will be randomly assigned to an intervention group: either the 'short sleep group' or the 'long sleep group'. In each group, participants will complete two study weeks. During a study week, participants will initially sleep for three nights for 8 hours, and then for three nights depending on group assignment either 6 hours (short sleep group) or 9.5 hours (long sleep group). Before the last night, participants will receive a capsule containing either caffeine (2 mg/kg) or placebo, and various cognitive tests will be measured as well as sleep via electroencephalography. On the evening after the last night, participants will again be asked to swallow a capsule (caffeine or placebo) and brain activity will be measured in a magnetic resonance imager.
(BASEC)
Malattie studiate
We are investigating the effects of caffeine in healthy teenagers.
(BASEC)
Age ≥ 14 and ≤ 17 Clinically healthy Signed informed consent from the participant Signed informed consent from the legal guardian (BASEC)
Criteri di esclusione
extremely short or long sleep duration (subjective sleep duration on school days <7h or >9h) Self-reported habitual caffeine consumption: self-reported regular daily intake of more than 50 mg/day; self-reported high sensitivity to caffeine or occurrence of discomfort after caffeine intake < 400 mg; caffeine-naive BMI-PC < P3 or BMI-PC > P97 (BASEC)
Luogo dello studio
Basilea
(BASEC)
Sponsor
Carolin Reichert
(BASEC)
Contatto per ulteriori informazioni sullo studio
Persona di contatto in Svizzera
Dr. Carolin Reichert
+41613255508
carolin.reichert@clutterupk.chCentre for Chronobiology, UPK Basel
(BASEC)
Informazioni scientifiche
non disponibile
Nome del comitato etico approvante (per studi multicentrici solo il comitato principale)
Commissione d'etica svizzera nord-ovest/centrale EKNZ
(BASEC)
Data di approvazione del comitato etico
23.06.2022
(BASEC)
ID di studio ICTRP
non disponibile
Titolo ufficiale (approvato dal comitato etico)
Consequences of caffeine intake in teenagers: Effects on sleep, reward processing, risk-taking, and underlying cerebral mechanisms under conditions of sleep restriction (BASEC)
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