Caffeine Consumption in Teenagers: Effects on Sleep, Reward Processing, and Risk-Taking After Reduced Sleep Duration
Résumé de l'étude
Teenagers often do not get enough sleep. Due to maturation-related changes, the biologically optimal sleep window does not align with early school start times, leading to sleep deprivation. To cope with the resulting daytime fatigue, some turn to caffeine. It is unclear what effects caffeine has on subsequent nighttime sleep under these conditions. Additionally, it is largely unexplored whether and how the two factors 'sleep deprivation' and 'caffeine' separately, but also in interaction, influence adolescents' risk behavior and their sensitivity to reward. We aim to systematically investigate this in this project.
(BASEC)
Intervention étudiée
Each participant will be randomly assigned to an intervention group: either the 'short sleep group' or the 'long sleep group'. In each group, participants will complete two study weeks. During a study week, participants will initially sleep for three nights for 8 hours, and then for three nights depending on group assignment either 6 hours (short sleep group) or 9.5 hours (long sleep group). Before the last night, participants will receive a capsule containing either caffeine (2 mg/kg) or placebo, and various cognitive tests will be measured as well as sleep via electroencephalography. On the evening after the last night, participants will again be asked to swallow a capsule (caffeine or placebo) and brain activity will be measured in a magnetic resonance imager.
(BASEC)
Maladie en cours d'investigation
We are investigating the effects of caffeine in healthy teenagers.
(BASEC)
Age ≥ 14 and ≤ 17 Clinically healthy Signed informed consent from the participant Signed informed consent from the legal guardian (BASEC)
Critères d'exclusion
extremely short or long sleep duration (subjective sleep duration on school days <7h or >9h) Self-reported habitual caffeine consumption: self-reported regular daily intake of more than 50 mg/day; self-reported high sensitivity to caffeine or occurrence of discomfort after caffeine intake < 400 mg; caffeine-naive BMI-PC < P3 or BMI-PC > P97 (BASEC)
Lieu de l’étude
Bâle
(BASEC)
Sponsor
Carolin Reichert
(BASEC)
Contact pour plus d'informations sur l'étude
Personne de contact en Suisse
Dr. Carolin Reichert
+41613255508
carolin.reichert@clutterupk.chCentre for Chronobiology, UPK Basel
(BASEC)
Informations scientifiques
non disponible
Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)
Ethikkommission Nordwest- und Zentralschweiz EKNZ
(BASEC)
Date d'approbation du comité d'éthique
23.06.2022
(BASEC)
Identifiant de l'essai ICTRP
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Titre officiel (approuvé par le comité d'éthique)
Consequences of caffeine intake in teenagers: Effects on sleep, reward processing, risk-taking, and underlying cerebral mechanisms under conditions of sleep restriction (BASEC)
Titre académique
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Titre public
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Maladie en cours d'investigation
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Intervention étudiée
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Type d'essai
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Plan de l'étude
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Critères d'inclusion/exclusion
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Critères d'évaluation principaux et secondaires
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Date d'enregistrement
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Inclusion du premier participant
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Sponsors secondaires
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Contacts supplémentaires
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ID secondaires
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Résultats-Données individuelles des participants
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Informations complémentaires sur l'essai
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Résultats de l'essai
Résumé des résultats
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Lien vers les résultats dans le registre primaire
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