Influence of low doses of LSD on visual perception
Descrizione riassuntiva dello studio
In this study, healthy participants are administered two times a low dose of LSD and one time an inactive substance ("placebo") on three different occasions in random order. Neither the participants nor the experimenter knows the order. After the substance administration, participants will perform computer tasks related to visual perception. Meanwhile, using electrodes attached to the head, electrical brain activity of the participants will be recorded. The study does not aim to evaluate health-related effects of LSD, but to test the effects of LSD on fundamental psychological processes.
(BASEC)
Intervento studiato
D-Lysergsäurediethylamid (0/10/20 mcg)
(BASEC)
Malattie studiate
Healthy participants
(BASEC)
– ≥18 and ≤65 years old – Body mass index 18-29 – Unimpaired or corrected (glasses/contact lenses) vision (BASEC)
Criteri di esclusione
– Severe acute or chronic illness – Current or past severe neurological or psychiatric illness (e.g., depression, anxiety disorder, or substance use disorder) – First-degree relative with an existing or past primary psychotic disorder (e.g., schizophrenia, schizoaffective disorder) or bipolar disorder (BASEC)
Luogo dello studio
Basilea
(BASEC)
Sponsor
Prof. Philipp Sterzer, Universitäre Psychiatrische Kliniken Basel
(BASEC)
Contatto per ulteriori informazioni sullo studio
Persona di contatto in Svizzera
Lucca Jaeckel, M.Sc.
+41 61 325 8151
Lucca.Jaeckel@clutterupk.chUniversitäre Psychiatrische Kliniken Basel
(BASEC)
Informazioni generali
University Psychiatric Clinics Basel,
+41 61 325 81 55;+41 61 325 81 55
Lucca.Jaeckel@clutterupk.ch(ICTRP)
Informazioni generali
University Psychiatric Clinics Basel
(ICTRP)
Informazioni scientifiche
University Psychiatric Clinics Basel,
+41 61 325 81 55;+41 61 325 81 55
Lucca.Jaeckel@clutterupk.ch(ICTRP)
Nome del comitato etico approvante (per studi multicentrici solo il comitato principale)
Commissione d'etica svizzera nord-ovest/centrale EKNZ
(BASEC)
Data di approvazione del comitato etico
30.06.2023
(BASEC)
ID di studio ICTRP
NCT05976698 (ICTRP)
Titolo ufficiale (approvato dal comitato etico)
Effects of LSD on perceptual decision-making in healthy subjects (BASEC)
Titolo accademico
Effects of LSD on Perceptual Decision-making in Healthy Subjects (ICTRP)
Titolo pubblico
LSD-Perceptual-Choice-Study (ICTRP)
Malattie studiate
LSD Reaction (ICTRP)
Intervento studiato
Drug: LSD 10 gDrug: LSD 20 gDrug: Placebo (ICTRP)
Tipo di studio
Interventional (ICTRP)
Disegno dello studio
Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Basic Science. Masking: Double (Participant, Investigator). (ICTRP)
Criteri di inclusione/esclusione
Inclusion Criteria:
- Willingness to adhere to the study protocol and sign the consent form
- = 18 and = 65 years of age at Screening
- Body mass index 18-29
- Fluent understanding of German
- Normal or corrected-to-normal vision
- Willingness to not operate a traffic vehicle or heavy machinery 24 hours after
substance administration
- Willingness to refrain from taking illicit psychoactive substances, including
cannabis, for the duration of the study
- Willingness to not consume more than one alcoholic standard drink the night before
the study sessions and not consume alcohol for 24 h after each study session
- Willingness to abstain from xanthine-based liquids from the evenings prior to the
study sessions and during the sessions
- Willingness to use effective birth-control throughout the study duration
- Adequate task performance in the decision-making tasks during a practice session in
the screening visit
Exclusion Criteria:
- Recent (<30 days) or current participation in another clinical trial
- Women that are pregnant, nursing, or planning to become pregnant during the study
period
- Current use of contraindicated/psychoactive medications or illicit drugs
- Lifetime use of classical psychedelics more than 20 times, or any time within the
previous two months
- Consumption of >5 cigarettes per day or >20 alcoholic standard drinks per week
- Severe chronic or acute medical condition
- Hypertension (>140/90 mmHg) or hypotension (<85mmHg systolic)
- Current or lifetime major mental health disorder
- Personal or family (first-degree) history of a primary psychotic disorder (ICTRP)
non disponibile
Endpoint primari e secondari
Change in changepoint task;Change in history bias task (ICTRP)
non disponibile
Data di registrazione
non disponibile
Inclusione del primo partecipante
non disponibile
Sponsor secondari
University of Basel;University Psychiatric Clinics Basel (ICTRP)
Contatti aggiuntivi
Philipp Sterzer, Prof. Dr.;Philipp Sterzer, Prof. Dr.;Philipp Sterzer, Prof.Dr., philipp.sterzer@upk.ch, +41 61 325 81 55;+41 61 325 81 55, University Psychiatric Clinics Basel, (ICTRP)
ID secondari
2023-00763, pk23Sterzer (ICTRP)
Risultati-Dati individuali dei partecipanti
non disponibile
Ulteriori informazioni sullo studio
https://clinicaltrials.gov/ct2/show/NCT05976698 (ICTRP)
Risultati dello studio
Riepilogo dei risultati
non disponibile
Link ai risultati nel registro primario
non disponibile