Influence of low doses of LSD on visual perception
Résumé de l'étude
In this study, healthy participants are administered two times a low dose of LSD and one time an inactive substance ("placebo") on three different occasions in random order. Neither the participants nor the experimenter knows the order. After the substance administration, participants will perform computer tasks related to visual perception. Meanwhile, using electrodes attached to the head, electrical brain activity of the participants will be recorded. The study does not aim to evaluate health-related effects of LSD, but to test the effects of LSD on fundamental psychological processes.
(BASEC)
Intervention étudiée
D-Lysergsäurediethylamid (0/10/20 mcg)
(BASEC)
Maladie en cours d'investigation
Healthy participants
(BASEC)
– ≥18 and ≤65 years old – Body mass index 18-29 – Unimpaired or corrected (glasses/contact lenses) vision (BASEC)
Critères d'exclusion
– Severe acute or chronic illness – Current or past severe neurological or psychiatric illness (e.g., depression, anxiety disorder, or substance use disorder) – First-degree relative with an existing or past primary psychotic disorder (e.g., schizophrenia, schizoaffective disorder) or bipolar disorder (BASEC)
Lieu de l’étude
Bâle
(BASEC)
Sponsor
Prof. Philipp Sterzer, Universitäre Psychiatrische Kliniken Basel
(BASEC)
Contact pour plus d'informations sur l'étude
Personne de contact en Suisse
Lucca Jaeckel, M.Sc.
+41 61 325 8151
Lucca.Jaeckel@clutterupk.chUniversitäre Psychiatrische Kliniken Basel
(BASEC)
Informations générales
University Psychiatric Clinics Basel,
+41 61 325 81 55;+41 61 325 81 55
Lucca.Jaeckel@clutterupk.ch(ICTRP)
Informations générales
University Psychiatric Clinics Basel
(ICTRP)
Informations scientifiques
University Psychiatric Clinics Basel,
+41 61 325 81 55;+41 61 325 81 55
Lucca.Jaeckel@clutterupk.ch(ICTRP)
Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)
Ethikkommission Nordwest- und Zentralschweiz EKNZ
(BASEC)
Date d'approbation du comité d'éthique
30.06.2023
(BASEC)
Identifiant de l'essai ICTRP
NCT05976698 (ICTRP)
Titre officiel (approuvé par le comité d'éthique)
Effects of LSD on perceptual decision-making in healthy subjects (BASEC)
Titre académique
Effects of LSD on Perceptual Decision-making in Healthy Subjects (ICTRP)
Titre public
LSD-Perceptual-Choice-Study (ICTRP)
Maladie en cours d'investigation
LSD Reaction (ICTRP)
Intervention étudiée
Drug: LSD 10 gDrug: LSD 20 gDrug: Placebo (ICTRP)
Type d'essai
Interventional (ICTRP)
Plan de l'étude
Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Basic Science. Masking: Double (Participant, Investigator). (ICTRP)
Critères d'inclusion/exclusion
Inclusion Criteria:
- Willingness to adhere to the study protocol and sign the consent form
- = 18 and = 65 years of age at Screening
- Body mass index 18-29
- Fluent understanding of German
- Normal or corrected-to-normal vision
- Willingness to not operate a traffic vehicle or heavy machinery 24 hours after
substance administration
- Willingness to refrain from taking illicit psychoactive substances, including
cannabis, for the duration of the study
- Willingness to not consume more than one alcoholic standard drink the night before
the study sessions and not consume alcohol for 24 h after each study session
- Willingness to abstain from xanthine-based liquids from the evenings prior to the
study sessions and during the sessions
- Willingness to use effective birth-control throughout the study duration
- Adequate task performance in the decision-making tasks during a practice session in
the screening visit
Exclusion Criteria:
- Recent (<30 days) or current participation in another clinical trial
- Women that are pregnant, nursing, or planning to become pregnant during the study
period
- Current use of contraindicated/psychoactive medications or illicit drugs
- Lifetime use of classical psychedelics more than 20 times, or any time within the
previous two months
- Consumption of >5 cigarettes per day or >20 alcoholic standard drinks per week
- Severe chronic or acute medical condition
- Hypertension (>140/90 mmHg) or hypotension (<85mmHg systolic)
- Current or lifetime major mental health disorder
- Personal or family (first-degree) history of a primary psychotic disorder (ICTRP)
non disponible
Critères d'évaluation principaux et secondaires
Change in changepoint task;Change in history bias task (ICTRP)
non disponible
Date d'enregistrement
non disponible
Inclusion du premier participant
non disponible
Sponsors secondaires
University of Basel;University Psychiatric Clinics Basel (ICTRP)
Contacts supplémentaires
Philipp Sterzer, Prof. Dr.;Philipp Sterzer, Prof. Dr.;Philipp Sterzer, Prof.Dr., philipp.sterzer@upk.ch, +41 61 325 81 55;+41 61 325 81 55, University Psychiatric Clinics Basel, (ICTRP)
ID secondaires
2023-00763, pk23Sterzer (ICTRP)
Résultats-Données individuelles des participants
non disponible
Informations complémentaires sur l'essai
https://clinicaltrials.gov/ct2/show/NCT05976698 (ICTRP)
Résultats de l'essai
Résumé des résultats
non disponible
Lien vers les résultats dans le registre primaire
non disponible