The effect of Platelet Rich Plasma (PRP) on the postoperative course after pancreatic surgeries

Résumé de l'étude

In various medical fields, Platelet Rich Plasma (PRP) is described as having a "healing" effect. Approximately 5-10 ml of blood is taken from the patient and isolated using a centrifugation system to obtain the PRP. This is routinely injected locally, for example, in sports injuries, to accelerate healing. In visceral surgery, we also rely on optimal healing after surgeries in the abdominal cavity. Particularly, surgeries on the pancreas are especially prone to complications due to the softness of the organ and aggressive digestive enzymes (amylase). Therefore, it would be of particular interest to develop measures that improve the postoperative healing of the pancreas. In this study, we investigate for the first time the effect of PRP on healing after pancreatic surgeries. In the operating room, 10 ml of blood is taken, and the PRP is obtained from your own blood. Your PRP will then be used to cover the severed area of the pancreas during the operation. No further interventions will be required afterwards. In case of postoperative complications, these will be anonymized and recorded in our database at the Cantonal Hospital of Winterthur (KSW). The complications will be compared with patients who have previously undergone pancreatic surgery at KSW without the addition of PRP.

(BASEC)

Intervention étudiée

In the operating room, approximately 10 ml of blood is taken. From the blood, the platelet-rich plasma (PRP) is isolated using the ACP system from Arthrex. The ACP system is routinely used for medical applications at KSW. The PRP is then applied to the severed area of the pancreas during the operation.

(BASEC)

Maladie en cours d'investigation

Various disease patterns and especially types of cancer necessitate surgeries on the pancreas (pankreas). Inevitably, pancreatic tissue is severed. This can lead to postoperative leaks of the pancreatic duct, allowing pancreatic fluid to enter the abdominal cavity. These leaks are referred to as pancreatic fistulas and occur in up to 30% of cases. These fistulas are the main reason for severe complications after pancreatic surgeries. In this study, we investigate factors from the patient's own blood that may improve the healing of the pancreas and thus reduce the rate of fistulas. For this purpose, blood is taken in the operating room, and the fraction rich in platelets (Platelet Rich Plasma, PRP) is isolated. This platelet-enriched fraction (PRP) is then applied to the pancreas. The extraction of PRP is a standardized procedure and is routinely used, for example, in plastic surgery, orthopedics, and rheumatology.

(BASEC)

Sponsor

non disponible

Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)

Commission cantonale de Zurich

(BASEC)

Date d'approbation du comité d'éthique

06.01.2023

(BASEC)

Résultats de l'essai