The role of arousal in sleep and wakefulness
Résumé de l'étude
In our research project, we are interested in the role of arousal levels during wake and sleep phases. In the first experiment, we investigate arousal changes during sleep in response to stimuli. In the second experiment, we examine self-regulation of arousal and its effect on subsequent sleep. Your pupil diameter will be measured during sleep. Depending on the experiment, either the arousal system will be tested during sleep using quiet stimuli, or you will actively modulate your arousal state before sleep. The study will take place in a sleep laboratory at ETH Zurich. All participants will first undergo a screening phase (telephone interview and, if necessary, a trial sleep period). In the experimental phase, between 1-3 sessions will be conducted, each lasting approximately 5-12 hours. Depending on the experiment, a so-called compliance phase of up to 5 days will take place before each session, during which you will wear an activity monitor and fill out short questionnaires daily. On the experimental day, recording devices (e.g., ECG, EEG) will be attached. Behavioral tasks will then follow during the recording of brain activity, pupil activity, and cardiovascular parameters (e.g., pulse). After that, the sleep period will follow, during which brain activity, pupil activity, and cardiovascular parameters will be continuously recorded. After waking up, there will again be a recording of brain activity and cardiovascular parameters while you are awake and performing behavioral tasks. All recording devices will then be removed. Number and effort of visits: If multiple trial nights are required, the experimental nights will take place at intervals of 3 days to 3 weeks, ideally the interval will be 1 week. Duration: Between 1 day and 21 days (ideally)
(BASEC)
Intervention étudiée
Self-regulation of arousal and its effect on subsequent sleep.
(BASEC)
Maladie en cours d'investigation
Only healthy subjects will participate in this study.
(BASEC)
-Good German language skills -18-50 years old men and women -Good health condition (BASEC)
Critères d'exclusion
-Illness (long-term, e.g., neurological, eye-related, psychological, internal, sleep disorders, hearing impairment) -Irregular sleep-wake rhythm -Regular medication intake that may significantly influence study results (e.g., sleeping pills, medications affecting the arousal system, isotretinoin) (BASEC)
Lieu de l’étude
Zurich
(BASEC)
Sponsor
Nicole Wenderoth, Prof. Dr. ETH Zurich
(BASEC)
Contact pour plus d'informations sur l'étude
Personne de contact en Suisse
Nicole Wenderoth, Prof. Dr. , Manuel Carro Dominguez, Dr.
+41 44 633 29 37
manuel.carrodominguez@clutterhest.ethz.chETH Zurich
(BASEC)
Informations scientifiques
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Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)
Commission cantonale de Zurich
(BASEC)
Date d'approbation du comité d'éthique
13.05.2022
(BASEC)
Identifiant de l'essai ICTRP
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Titre officiel (approuvé par le comité d'éthique)
Investigating the role of the arousal system during wake and sleep via pupil-based observational and modulation techniques (BASEC)
Titre académique
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Titre public
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Maladie en cours d'investigation
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Intervention étudiée
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Type d'essai
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Plan de l'étude
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Critères d'inclusion/exclusion
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Critères d'évaluation principaux et secondaires
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Date d'enregistrement
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Inclusion du premier participant
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Sponsors secondaires
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Contacts supplémentaires
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ID secondaires
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Résultats-Données individuelles des participants
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Informations complémentaires sur l'essai
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Résultats de l'essai
Résumé des résultats
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Lien vers les résultats dans le registre primaire
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