The role of arousal in sleep and wakefulness

Zusammenfassung der Studie

In our research project, we are interested in the role of arousal levels during wake and sleep phases. In the first experiment, we investigate arousal changes during sleep in response to stimuli. In the second experiment, we examine self-regulation of arousal and its effect on subsequent sleep. Your pupil diameter will be measured during sleep. Depending on the experiment, either the arousal system will be tested during sleep using quiet stimuli, or you will actively modulate your arousal state before sleep. The study will take place in a sleep laboratory at ETH Zurich. All participants will first undergo a screening phase (telephone interview and, if necessary, a trial sleep period). In the experimental phase, between 1-3 sessions will be conducted, each lasting approximately 5-12 hours. Depending on the experiment, a so-called compliance phase of up to 5 days will take place before each session, during which you will wear an activity monitor and fill out short questionnaires daily. On the experimental day, recording devices (e.g., ECG, EEG) will be attached. Behavioral tasks will then follow during the recording of brain activity, pupil activity, and cardiovascular parameters (e.g., pulse). After that, the sleep period will follow, during which brain activity, pupil activity, and cardiovascular parameters will be continuously recorded. After waking up, there will again be a recording of brain activity and cardiovascular parameters while you are awake and performing behavioral tasks. All recording devices will then be removed. Number and effort of visits: If multiple trial nights are required, the experimental nights will take place at intervals of 3 days to 3 weeks, ideally the interval will be 1 week. Duration: Between 1 day and 21 days (ideally)

(BASEC)

Untersuchte Intervention

Self-regulation of arousal and its effect on subsequent sleep.

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Untersuchte Krankheit(en)

Only healthy subjects will participate in this study.

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Sponsor

Nicole Wenderoth, Prof. Dr. ETH Zurich

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Name der bewilligenden Ethikkommission (bei multizentrischen Studien nur die Leitkommission)

Ethikkommission Zürich

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Datum der Bewilligung durch die Ethikkommission

13.05.2022

(BASEC)

Ergebnisse der Studie