Study of delirium in intensive care using brain PET scan at the patient's bedside: the PETITION-ICU study
Descrizione riassuntiva dello studio
Delirium is a common complication in intensive care units. It is characterized by inattention, disordered thinking, and cognitive disturbances (memory and reasoning disorders). In the intensive care unit at CHUV, 60% of mechanically ventilated patients develop a state of delirium. This figure can reach 80% in some intensive care units. The condition has been known for a long time, but the mechanisms involved are still unknown. There are risk factors that promote its development, such as certain medications. We aim to understand the link between the method of sedation, the effects of prolonged mechanical ventilation, and the duration of the delirium state. This project is a pilot study, and the medical device is being used for the first time on humans. This new medical device (medical equipment) is a scaled-down model of the PET (Positron Emission Tomography) scanners found in hospitals. There is no additional risk associated with its use. Furthermore, as the PETITION-ICU scanner is attached to the head of the patient's bed, we do not need to disconnect life-supporting devices or transport the patient to the imaging room, which reduces the risks associated with transporting intensive care patients to the nuclear medicine department.
(BASEC)
Intervento studiato
During this study, a contrast agent that allows visualization of sugar consumption in different parts of the brain will be injected into the participant. One hour after the injection of the contrast agent, a scan will be performed at the patient's bedside using a prototype PET scanner. This miniaturized scanner allows for a sequence of images of the patient's brain to be taken directly in their bed, without having to move them to the imaging department.
(BASEC)
Malattie studiate
Delirium is a common complication for ventilated patients that generally occurs 72 hours after the start of ventilation and can affect 60% of mechanically ventilated patients in intensive care. It is characterized by inattention, disordered thinking, and cognitive disturbances (memory and reasoning disorders).
(BASEC)
- be over 18 years old - requiring sedation and mechanical ventilation for at least 48 hours - blood sugar levels between 8.3 and 11 mmol/L (BASEC)
Criteri di esclusione
- acute brain injuries - known cognitive impairment - severe renal or hepatic injury (BASEC)
Luogo dello studio
Losanna
(BASEC)
Sponsor
Centre Hospitalier Universitaire
(BASEC)
Contatto per ulteriori informazioni sullo studio
Persona di contatto in Svizzera
Prof. John Prior
0795568702
john.prior@clutterchuv.chCentre Hospitalier Universitaire
(BASEC)
Informazioni scientifiche
non disponibile
Nome del comitato etico approvante (per studi multicentrici solo il comitato principale)
Commissione d'etica Vaud
(BASEC)
Data di approvazione del comitato etico
14.08.2025
(BASEC)
ID di studio ICTRP
non disponibile
Titolo ufficiale (approvato dal comitato etico)
Exploration of FDG Positron Emission Tomography (PET) patterns of cerebral glucose metabolism in critically ill patients with delirium : “PETITION-ICU Study” (BASEC)
Titolo accademico
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Titolo pubblico
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Malattie studiate
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Intervento studiato
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Tipo di studio
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Disegno dello studio
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Criteri di inclusione/esclusione
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Endpoint primari e secondari
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Data di registrazione
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Inclusione del primo partecipante
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Sponsor secondari
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Contatti aggiuntivi
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ID secondari
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Risultati-Dati individuali dei partecipanti
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Ulteriori informazioni sullo studio
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Risultati dello studio
Riepilogo dei risultati
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Link ai risultati nel registro primario
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