Treatment of Chronic Itching through Targeted Influence on Sensory Processing in the Brain
Résumé de l'étude
Chronic itching is one of the most common symptoms in dermatological patients. The impact on quality of life can be significant. The causes of itching vary and range from skin and nerve diseases to liver and kidney disorders. The brain is always involved in sensory processing. Treating itching is often challenging. In psychotherapeutic treatments using 'Eye Movement Desensitisation and Reprocessing' (EMDR) for patients with accompanying skin diseases and chronic itching, we observed an improvement in itching complaints. There are additional case reports that also describe the effectiveness of EMDR for itching. However, potential correlations have not yet been sufficiently researched, which is why we are pursuing this study. In this study, we first investigate whether the intervention method EMDR is feasible for chronic itching in an interdisciplinary setting of psychosomatics and dermatology and whether it is accepted by the affected individuals. This can provide initial important insights into effectiveness and good tolerability. If the effectiveness of EMDR for itching is scientifically examined and proven, it can be specifically used against chronic itching.
(BASEC)
Intervention étudiée
The intervention method EMDR is currently used for the treatment of post-traumatic stress disorders. EMDR stands for 'Eye Movement Desensitisation and Reprocessing': This method influences sensory processing through guided eye movements (similar to REM sleep) or alternative bilateral stimulation of both hemispheres of the brain. Due to its good effectiveness and tolerability, EMDR has been continuously expanding its application area in Europe and the USA in recent years.
In our study, participants will be grouped in consultation with our study team. This is important to obtain reliable results from the study. There are two groups in our study: an intervention group (Group 1) and a comparison group (Group 2). Both groups receive the treatment that is customary for the given diagnosis according to current knowledge. The intervention group additionally receives EMDR therapy.
The study is not a blinded study. Not blinded means that everyone involved in the implementation knows which group the participants have been assigned to. The participants themselves also know which group they are in.
(BASEC)
Maladie en cours d'investigation
chronic itching
(BASEC)
diagnosed chronic itching Age between 18-75 years Itching intensity of at least 4 on the 0-10 numerical rating scale within the last 7 days (BASEC)
Critères d'exclusion
Patients with phototherapy Inability to follow the study process, e.g., due to language problems or severe mental illnesses Acute outbreak of an autoimmune disease such as Crohn's disease (BASEC)
Lieu de l’étude
Bâle
(BASEC)
Sponsor
Universitätsspital Basel
(BASEC)
Contact pour plus d'informations sur l'étude
Personne de contact en Suisse
Dr. med. Chrysovalandis Schwale
+41 61 328 3121
chrysovalandis.schwale@clutterusb.chUniversitätsspital Basel
(BASEC)
Informations générales
University Hospital, Basel, Switzerland,
+41 61 265 52 94;+41 61 265 52 94
chrysovalandis.schwale@clutterusb.ch(ICTRP)
Informations scientifiques
University Hospital, Basel, Switzerland,
+41 61 265 52 94;+41 61 265 52 94
chrysovalandis.schwale@clutterusb.ch(ICTRP)
Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)
Ethikkommission Nordwest- und Zentralschweiz EKNZ
(BASEC)
Date d'approbation du comité d'éthique
28.05.2025
(BASEC)
Identifiant de l'essai ICTRP
NCT06771375 (ICTRP)
Titre officiel (approuvé par le comité d'éthique)
Eye movement desensitization and reprocessing (EMDR) to treat chronic pruritus in a multidisciplinary tertiary care setting– a feasibility study (BASEC)
Titre académique
Eye Movement Desensitization and Reprocessing (EMDR) to Treat Chronic Pruritus in a Multidisciplinary Tertiary Care Setting- a Feasibility Study (ICTRP)
Titre public
Eye Movement Desensitization and Reprocessing (EMDR) to Treat Chronic Pruritus (ICTRP)
Maladie en cours d'investigation
Chronic Pruritus (ICTRP)
Intervention étudiée
Behavioral: Eye Movement Desensitization and Reprocessing (ICTRP)
Type d'essai
Interventional (ICTRP)
Plan de l'étude
Allocation: Non-Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: None (Open Label). (ICTRP)
Critères d'inclusion/exclusion
Gender: All
Maximum age: 75 Years
Minimum age: 18 Years
Inclusion Criteria:
- Provided written informed consent
- Age 18 to 75 years
- Skindex-29 (questionnaire) symptoms subscale =42
- Confirmed diagnosis CP
- Itch intensity of min. = 4 on the 0-10 numerical rating scale within the last 7 days
- Stable course of treatment in the two weeks prior to the study
Exclusion Criteria:
- Inability to follow the procedures of the study, e.g. due to language problems,
severe psychiatric disorders such as delusional disorder, suicidality or dementia.
- Patients on phototherapy
- Acute attacks of an autoimmune disease such as Crohn's disease
- Serious cardiac disease (ICTRP)
non disponible
Critères d'évaluation principaux et secondaires
Adherence (%) (ICTRP)
non disponible
Date d'enregistrement
non disponible
Inclusion du premier participant
non disponible
Sponsors secondaires
non disponible
Contacts supplémentaires
Chrysovalandis Schwale, Dr.;Chrysovalandis Schwale, Dr.;Chrysovalandis Schwale, Dr. med., chrysovalandis.schwale@usb.ch, +41 61 265 52 94;+41 61 265 52 94, University Hospital, Basel, Switzerland, (ICTRP)
ID secondaires
2024-02597, th24schaefert (ICTRP)
Résultats-Données individuelles des participants
non disponible
Informations complémentaires sur l'essai
https://clinicaltrials.gov/ct2/show/NCT06771375 (ICTRP)
Résultats de l'essai
Résumé des résultats
non disponible
Lien vers les résultats dans le registre primaire
non disponible