Study with young women to investigate the effects of chitin and vitamin C on iron absorption from edible mealworm larvae.
Résumé de l'étude
Animal foods are important sources of well-absorbed iron in human nutrition. Given the growing world population, sustainable iron sources must be identified, as increasing meat production is not desirable to achieve climate protection goals. A previous study showed that insect iron is moderately well absorbed. This study investigates whether chitin, a polysaccharide in insect biomass, reduces iron absorption. Additionally, the addition of vitamin C is attempted to increase iron absorption from insects. This knowledge may lead to optimizing the composition of an insect-based meal to enhance iron absorption. To measure iron absorption from insect biomass, insects are labeled with stable iron isotopes, and iron absorption in the blood is determined. Young women will participate in the study. When iron is administered in the form of stable isotopes, no adverse events are expected, as these occur naturally in our body, and the stable isotopes used are not radioactive.
(BASEC)
Intervention étudiée
The investigational product is edible mealworm larvae (Tenebrio molitor), whose feed is enriched with stable iron isotopes during growth to obtain intrinsically labeled insects with stable iron isotopes. The participants will receive the mealworm larvae alone, with additional chitin, or with ascorbic acid (vitamin C).
(BASEC)
Maladie en cours d'investigation
Iron is involved in vital metabolic processes such as oxygen transport from the lungs to tissues, electron transport in cells, DNA synthesis and repair, and muscle metabolism. However, many people are still affected by iron deficiency and iron deficiency anemia, particularly preschool children (<5 years), adolescents, and pregnant and non-pregnant women of childbearing age. Iron deficiency is characterized by a lack of total iron in the body, which is primarily caused by insufficient dietary iron intake, a physiologically increased iron requirement, poor intestinal iron absorption, or chronic blood loss.
(BASEC)
Female, 18 – 45 years old Body weight < 70 KG Normal Body Mass Index (18.5 – 24.9 kg/m2) Low iron status (falls in the lower half of the serum ferritin distribution during screening) Good English language skills (BASEC)
Critères d'exclusion
Pregnancy Breastfeeding up to 6 weeks before the study begins Food allergies, specifically to crustaceans, dust mites, and seafood Anemia (hemoglobin < 12 g/dL) Increased CRP concentration (> 5.0 mg/L) Chronic gastrointestinal, kidney, and metabolic diseases (BASEC)
Lieu de l’étude
Zurich
(BASEC)
Sponsor
Prof. Dr. Diego Moretti
(BASEC)
Contact pour plus d'informations sur l'étude
Personne de contact en Suisse
Laila Hammer
+41 44 512 09 63
laila.hammer@clutterffhs.chFernfachhochschule Schweiz
(BASEC)
Informations scientifiques
non disponible
Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)
Commission cantonale de Zurich
(BASEC)
Date d'approbation du comité d'éthique
14.03.2025
(BASEC)
Identifiant de l'essai ICTRP
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Titre officiel (approuvé par le comité d'éthique)
he effect of chitin and ascorbic acid on dietary iron absorption from Tenebrio molitor larvae in young women. (BASEC)
Titre académique
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Titre public
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Maladie en cours d'investigation
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Intervention étudiée
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Type d'essai
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Plan de l'étude
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Critères d'inclusion/exclusion
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Critères d'évaluation principaux et secondaires
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Date d'enregistrement
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Inclusion du premier participant
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Sponsors secondaires
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Contacts supplémentaires
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ID secondaires
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Résultats-Données individuelles des participants
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Informations complémentaires sur l'essai
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Résultats de l'essai
Résumé des résultats
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Lien vers les résultats dans le registre primaire
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