Management of grammatical time marking in post-stroke aphasia: study with French-speaking subjects suffering from fluent and non-fluent aphasia in chronic stage
Résumé de l'étude
This study aims to evaluate the effectiveness of speech therapy (individual or group) focusing on grammatical time marking, targeted at the underlying deficient processes. The main objective will be to assess whether the proposed therapy improves the grammatical time marking of the items worked on in sessions. We will also examine whether the observed progress generalizes to untreated items and to more ecological contexts (related to the subject's daily life), as well as whether the observed progress is maintained at 2 weeks and at 1 month post-therapy. The management will be offered to several French-speaking aphasic individuals (fluent and non-fluent) in chronic stage suffering from difficulties in referring to time through verb inflection. Two modalities of management will be proposed: individual and group. The first part of the study, proposing individual management, will include between four and five participants with brain injuries. The second part of the study, proposing group management, will include four participants with brain injuries (two groups of two participants). The therapy will last 1 month with 3 weekly sessions of about one hour.
(BASEC)
Intervention étudiée
The management focuses on grammatical time marking. Whether individual or group, the management aims to work on the underlying processes of grammatical time marking identified as deficient during a preliminary assessment. The intervention consists of 4 steps inspired by models and hypotheses from the literature on the subject. 1) In step 1 "selection of temporal adverbials", the subject must identify the time encoded in sentences (via the temporal diacritic features contained in the inflected verb), then select the correct adverbial from those proposed. 2) In step 2 "selection of inflected verb forms", the subject must translate the time encoded in the sentence (via the temporal adverbials) into temporal diacritic features to select the correct verb form from those proposed. 3) In step 3 "production of inflected verb forms", the subject produces inflected verbs. To do this, they must translate the time encoded in the message (via the temporal adverbials) into temporal diacritic features and retrieve the correct verb form corresponding to the encoded time. 4) In step 4 "semantic narration", the subject describes imagined scenes using inflected verbs according to the previously defined reference time.
(BASEC)
Maladie en cours d'investigation
Disorders of grammatical time marking post-stroke
(BASEC)
- Must have been a victim, in adulthood, of a stroke (AVC) evidenced by imaging and causing aphasia (fluent or non-fluent). The interval between the stroke and participation in this study must be greater than 6 months. - Must be a native French speaker or have excellent command of French. - Must present disorders of grammatical time marking evidenced by a language examination. (BASEC)
Critères d'exclusion
- Must present chronic symptoms of a substance use disorder related to alcohol or drugs (according to DSM-V criteria). - Must present significant uncorrected visual and/or hearing impairments. - Must present significant disorders of oral/written verbal comprehension. (BASEC)
Lieu de l’étude
Fribourg, Neuchâtel
(BASEC)
Sponsor
Université de Neuchâtel
(BASEC)
Contact pour plus d'informations sur l'étude
Personne de contact en Suisse
Célia Ericson
+41 32 718 17 34
celia.ericson@clutterunine.chUniversité de Neuchâtel
(BASEC)
Nom du comité d'éthique approbateur (pour les études multicentriques, uniquement le comité principal)
Commission cantonale d'éthique du Vaud
(BASEC)
Date d'approbation du comité d'éthique
13.02.2023
(BASEC)
Identifiant de l'essai ICTRP
NCT05656638 (ICTRP)
Titre officiel (approuvé par le comité d'éthique)
Treatment of Grammatical Time Marking in Post-Stroke Aphasia (BASEC)
Titre académique
Treatment of Grammatical Time Marking in Post-Stroke Aphasia: a Study of French-Speaking Subjects With Chronic Fluent and Non-fluent Aphasia (ICTRP)
Titre public
Treatment of Grammatical Time Marking in Post-Stroke Aphasia (ICTRP)
Maladie en cours d'investigation
Brain Injury, Vascular;Aphasia;Stroke (ICTRP)
Intervention étudiée
Behavioral: Speech and language therapy (ICTRP)
Type d'essai
Interventional (ICTRP)
Plan de l'étude
Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Treatment. Masking: None (Open Label). (ICTRP)
Critères d'inclusion/exclusion
Gender: All
Maximum age: 75 Years
Minimum age: 18 Years
Inclusion Criteria:
- Have had an imaging-objectified stroke in adulthood that resulted in aphasia (fluent
or non-fluent). The time between the stroke and participation in this study must be
greater than 6 months.
- Be a native French speaker or have excellent mastery of French.
- Be between 18 and 75 years old.
- Present grammatical tense marking disorders objectified by language evaluation
(deficit scores on the "Batterie d'?valuation de la Production Syntaxique" (BEPS) verb
flexion task, Monetta et al., 2018; and/or on the "Test d'expression morpho-syntaxique
fine" (T.E.M.F.) active sentence production subtask, Bernaert-Paul and Simonin, 2011).
Exclusion Criteria:
- Present chronic symptoms of a substance use disorder as defined by Diagnostic and
Statistical Manual of Mental Disorders (DSM-V) criteria.
- Have significant uncorrected vision and/or hearing impairment.
- Have significant impairments in oral/written comprehension.
- Present apraxia of speech or a severe arthritic disorder
- Present hemineglect
- Present impaired judgment and discernment, objectified by a neuropsychological
evaluation
(ICTRP)
non disponible
Critères d'évaluation principaux et secondaires
Change from the score on an inflected verb production task after the end of the therapy: treated items;Change from time accuracy on a semantic narration task after the end of the therapy: treated semantic narrations;Change from the score on an inflected verb production task after the end of the therapy: untreated items;Change from time accuracy on a semantic narration task after the end of the therapy: untreated semantic narrations;Change from the score on an inflected verb production task 2 and 4 weeks after the end of the therapy: treated items;Change from the score on an inflected verb production task 2 and 4 weeks after the end of the therapy: untreated items;Change from time accuracy on a semantic narration task 2 and 4 weeks after the end of the therapy: treated semantic narrations;Change from time accuracy on a semantic narration task 2 and 4 weeks after the end of the therapy: untreated semantic narrations;Change from the score on an inflected verb production task 2 and 4 weeks after the end of the therapy: treated items;Change from the score on an inflected verb production task 2 and 4 weeks after the end of the therapy: untreated items;Change from time accuracy on a semantic narration task 2 and 4 weeks after the end of the therapy: treated semantic narrations;Change from time accuracy on a semantic narration task 2 and 4 weeks after the end of the therapy: untreated semantic narrations (ICTRP)
Change from time accuracy on an episodic/procedural narration task after the end of the therapy;Change from time accuracy on an episodic/procedural narration task 2 and 4 weeks after the end of the therapy;Change from time accuracy on an episodic/procedural narration task 2 and 4 weeks after the end of the therapy;Change at a control task after the end of the therapy;Change at a control task 2 and 4 weeks after the end of the therapy;Change at a control task 2 and 4 weeks after the end of the therapy (ICTRP)
Date d'enregistrement
non disponible
Inclusion du premier participant
non disponible
Sponsors secondaires
non disponible
Contacts supplémentaires
Marion Fossard;Marion Fossarf, marion.fossard@unine.ch, +41 32 718 18 95;+41 32 718 1895 (ICTRP)
ID secondaires
Unine2022-01807 (ICTRP)
Résultats-Données individuelles des participants
non disponible
Informations complémentaires sur l'essai
https://clinicaltrials.gov/ct2/show/NCT05656638 (ICTRP)
Résultats de l'essai
Résumé des résultats
non disponible
Lien vers les résultats dans le registre primaire
non disponible