Stool transplantation (Fecal Microbiota Transplantation – FMT) for patients with malignant tumors who do not respond to cancer immunotherapy

Switzerland (ICTRP)

ID di studio ICTRP
NCT05273255 (ICTRP)

Titolo ufficiale (approvato dal comitato etico)
non disponibile

Titolo accademico
An Open Label Feasibility Study of Fecal Microbiota Transplantation (FMT) in Patients With Malignancies Not Responding to Cancer Immunotherapy (CI) (ICTRP)

Titolo pubblico
Fecal Microbiota Transplantation in Patients With Malignancies Not Responding to Cancer Immunotherapy (ICTRP)

Malattie studiate
CancerFecal Microbiota TransplantationImmune Checkpoint InhibitorsImmunotherapy (ICTRP)

Intervento studiato
Biological: Fecal Microbiota Transplantation (FMT) (ICTRP)

Tipo di studio
Interventional (ICTRP)

Disegno dello studio
Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Other. Masking: None (Open Label). (ICTRP)

Criteri di inclusione/esclusione
General inclusion criteria for all participants:

- Patients, at minimum 18 years of age, male or female

- Signed informed consent obtained from subject according to local regulations

- ECOG score at the time of study enrolment 0-1

The investigators will include patients/individuals fulfilling inclusion criteria for one
of the following groups:

1. Patients with refractory malignancy (FMT-Recipients). The investigators will recruit
25 individuals with stable or progressing disease after minimum of 1 cycle of CI.

2. Patients with malignancy in remission after ICI therapy (FMT-Donors). The
investigators will recruit 5 patients willing to donate stool samples for the study.

Inclusion criteria FMT-Recipients:

1. Histologically or cytologically confirmed diagnosis of malignancy

2. Currently treated with CI with at least 1 cycle completed. Multiple active
malignancies are allowed.

3. Patient with stable or progressive disease as shown at the most recent staging
method and decided by the treating investigator (based on the radiologic
assessment).

4. Must be CI refractory/resistant as judged by the treating physician based on a
recent CT or PET-CT (PET-MRI) scan not older than 8 weeks before screening visit.

5. Willingness to receive FMT administered via colonoscopy and undergo necessary bowel
preparation pre-procedure.

6. Demonstrate adequate organ function as defined below, all screening labs should be
performed within 28 days of FMT intervention.

Following laboratory parameters need to be met:

- Platelet count = 50 x 10^9 / L

- Hemoglobin = 8.5 g/dL

- Prothrombin time (PT)-international normalized ration (INR) = 1.5

7. Female subject of childbearing potential should have a negative urine pregnancy
within minimum 8 hours prior to receiving the study intervention (FMT). If the urine
test is positive or cannot be confirmed as negative, a serum pregnancy test will be
required.

8. Female subjects of childbearing potential must be willing to use a clinically
established method of contraception before the FMT procedure.

Inclusion criteria FMT-Donors:

1. Documented history of malignancy treated with ICI therapy.

2. Featuring partial or complete response of the malignancy as assessed by radiologic
examination with a minimum duration of remission lasting =12 months measured since
initiation of therapy.

3. Willingness to complete donor-specific questionnaire.

4. Willingness to complete donor-specific serologic and stool testing to evaluate
infectious agents.

5. Patient tested negatively for all infectious agents specified.

6. Willingness to provide multiple stool samples, until total amount reaches 170g.

7. Absence of major gastrointestinal symptoms 3 months prior to stool donation
(including frequent vomiting, diarrhea, bleeding, constipation).

Exclusion criteria FMT Recipients:

1. Presence of absolute contra-indications to colonoscopy and/or FMT administration:

- Toxic megacolon

- Inflammatory bowel disease

- Anatomic contra-indications to colonoscopy

- Colectomy

2. Patient is currently participating and receiving other study therapy or has
participated in a study of an investigational agent and received study therapy or
used an investigational device within 4 weeks of this study intervention.

3. Currently under any form of systemic antibiotics.

4. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy (> 10
mg prednisone daily or equivalent) or any other form of immunosuppressive therapy
two weeks prior to trial treatment. Patients receiving systemic steroids at
physiologic doses are permitted to enroll assuming steroid dose is not above the
acceptable threshold (> 10 mg prednisone daily or equivalent).

5. Severe anaphylactic reaction to any food (food allergies).

6. Had a severe hypersensitivity reaction to propofol.

7. Has serious concomitant illnesses. The eligibility can be granted by the treating
investigator on individual bases.

8. Has HIV infection or AIDS-related illness.

9. Has active infection of HAV, HBV or HCV. Patients with a history of Hepatitis B/C
infection who have received anti-viral therapy and are disease free may be
considered for enrollment after discussion with Principal Investigator.

10. Patient has received a live vaccine within 4 weeks prior to the first dose of
treatment. Seasonal influenza vaccines or COVID-19 vaccines for injection are
generally inactivated virus vaccines and are allowed.

11. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.

12. Females who are pregnant or breastfeeding.

13. Active central nervous system (CNS) metastases and/or leptomeningeal involvement.

Exclusion criteria FMT Donors:

1. History or current antibiotic treatment during the 2 month preceding donation.

2. History or current intrinsic gastrointestinal illnesses, including inflammatory
bowel disease, irritable bowel syndrome, chronic diarrheal disorder (e.g. celiac
disease or microscopic colitis) or major gastrointestinal surgical procedures.

3. History or current symptomatic autoimmune illness.

4. History or current documented neurologic or neurodevelopmental disorders.

5. History or current metabolic syndrome, obesity (BMI of >35), or moderate-to-severe
malnutrition (as assessed clinically).

6. History or current infection with HIV (or AIDS-related illness).

7. Positive serological tests for Syphilis, HAV, HBV or HCV.

8. Positive stool test for Escherichia coli, Vancomycin-resistant Enterococcus,
Norovirus, C. difficile, Yersinia, Campylobacter, Shigella or Salmonella.

9. Positive stool test for parasites.

10. Positive Sars-CoV-2 screening/testing (active infection).

Subjects whose pregnancy test on Screening visit shows a positive result, have to be
excluded from the study. All pregnancies occurring during the treatment phase of the
study and within 30 days after discontinuation of study medication have to be reported to
the Investigator-Sponsor within one working day of the investigational sites knowledge of
the pregnancy on the Initial Pregnancy Report Form. Female Subjects should be informed in
this way before signing the informed consent form. Female partners of male participants
may get pregnant without any consequence to the male participant. (ICTRP)

non disponibile

Endpoint primari e secondari
Change in the intestinal microbiome community (ICTRP)

Adverse Events Related to Study Intervention;Objective Response Rate;Progression-Free Survival;Overall Survival;Correlation between specific immune cell presence in blood/colon tissue and therapy response;CI response rate upon microbiome change;Quality of life based on the questionnaire (ICTRP)

Data di registrazione
non disponibile

Inclusione del primo partecipante
non disponibile

Sponsor secondari
non disponibile

Contatti aggiuntivi
Michael Scharl, Prof. Dr., University Hospital Zurich, University of Zurich (ICTRP)

ID secondari
FMT-Malignancies (ICTRP)

Risultati-Dati individuali dei partecipanti
non disponibile

Ulteriori informazioni sullo studio
https://clinicaltrials.gov/ct2/show/NCT05273255 (ICTRP)