The immediate physiological reaction and sensation to eccentric training under blood flow restriction
Summary description of the study
In this study, we investigate how training under blood flow restriction with eccentric load (i.e., during the braking phase of the movement) affects the physiological systems (e.g., breathing and pulse) of your body and how you perceive the training. To compare the results, you will also perform traditional strength training. Your participation in this study will last a maximum of 2 weeks. We will invite you for 3 study visits. An appointment lasts about 1.5 hours.
(BASEC)
Intervention under investigation
Training under blood flow restriction with eccentric load (i.e., acting only during the braking phase of the movement)
(BASEC)
Disease under investigation
Healthy participants
(BASEC)
Healthy participants aged 18 years and older. (BASEC)
Exclusion criteria
If you have ever had a thrombosis in your legs or know that you are pregnant, you cannot participate in the study. In the study, you must perform strength training for the legs; if you experience pain during training, you cannot participate. (BASEC)
Trial sites
Zurich
(BASEC)
Sponsor
University of Zurich
(BASEC)
Contact
Contact Person Switzerland
Dr. Dario Kohlbrenner
+41 44 634 60 33
dario.kohlbrenner@clutteruzh.chEpidemiology, Biostatistics, and Prevention Institute University of Zurich
(BASEC)
Name of the authorising ethics committee (for multicentre studies, only the lead committee)
Ethics Committee Zurich
(BASEC)
Date of authorisation
31.01.2025
(BASEC)
ICTRP Trial ID
NCT06856629 (ICTRP)
Official title (approved by ethics committee)
The immediate physiological and perceptual response to blood-flow restricted strength training with eccentric loading (E-BFR): a randomised crossover study in healthy subjects (BASEC)
Academic title
The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training with Eccentric Loading (E-BFR): a Randomised Crossover Study in Healthy Subjects (ICTRP)
Public title
The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training with Eccentric Loading (ICTRP)
Disease under investigation
Healthy (ICTRP)
Intervention under investigation
Other: Eccentric blood-flow restriction trainingOther: Eccentric free-flow training (ICTRP)
Type of trial
Interventional (ICTRP)
Trial design
Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Other. Masking: None (Open Label). (ICTRP)
Inclusion/Exclusion criteria
Inclusion Criteria:
- Clinically Healthy
Exclusion Criteria:
- Physical or intellectual impairment precluding informed consent or protocol
adherence
- Pain during exercise of any origin
- History of thromboembolic event in the lower extremity
- Known pregnancy (no testing is carried out) (ICTRP)
not available
Primary and secondary end points
minute ventilation (ICTRP)
Other variables from breath-by-breath analysis;Rate of perceived exertion;Near-infrared spectroscopy of the vastus lateralis;Delayed onset muscle soreness;Feasibility and tolerability (ICTRP)
Registration date
not available
Incorporation of the first participant
not available
Secondary sponsors
not available
Additional contacts
Dario Kohlbrenner, PhDDario Kohlbrenner, PhD, dario.kohlbrenner@uzh.chdario.kohlbrenner@uzh.ch, +41 44 634 60 33+41 44 634 60 33 (ICTRP)
Secondary trial IDs
SNCTP000006261, BASEC2024-02223 (ICTRP)
Results-Individual Participant Data (IPD)
not available
Further information on the trial
https://clinicaltrials.gov/ct2/show/NCT06856629 (ICTRP)
Results of the trial
Results summary
not available
Link to the results in the primary register
not available