Immunotherapy for Cat Allergy by Injecting Allergen into the Lymph Node: Safety and Effects on the Immune System
Summary description of the study
Cat (hair) allergies are often difficult to treat and significantly affect those affected, as the allergens are hard to avoid. The only approved way to treat the allergy itself is currently subcutaneous immunotherapy. In this treatment, patients are "desensitized" to the allergen by injecting it under the skin in a low, gradually increasing dose. However, individuals with cat allergies often experience side effects during this treatment. A form of immunotherapy that has only been studied so far is called intralymphatic immunotherapy, where the allergen is injected directly into a lymph node under ultrasound control. This directly targets certain immune system cells. Fewer injections are needed compared to subcutaneous immunotherapy, and fewer side effects are expected. This therapy has already been applied in studies with various allergens and showed positive results, although it has been tested on relatively few patients so far. In this study, we aim to investigate whether intralymphatic immunotherapy is well tolerated and safe for cat allergy and whether it shows effects on cat allergy. In the first phase of the study, a well-tolerated and safe dose for the therapy will be determined, and in the second phase, the therapy will be conducted in three different treatment groups. These differ in the dosage of intralymphatic immunotherapy. The treatment will last for three months, followed by a follow-up phase of another three months.
(BASEC)
Intervention under investigation
Intralymphatic immunotherapy (immunotherapy by injecting the allergen into the lymph node)
(BASEC)
Disease under investigation
Cat (hair) allergy
(BASEC)
Cat allergy (BASEC)
Exclusion criteria
severe, uncontrolled asthma pregnancy chronic inflammatory or malignant diseases (BASEC)
Trial sites
Zurich
(BASEC)
Sponsor
Professor Pål Johansen, Universitätsspital Zürich
(BASEC)
Contact
Contact Person Switzerland
ILIT-Studienteam (Claudia Lang, Alexandra Steiger)
+41 (0)43 253 7855
ilit-studie@clutterusz.chDermatologische Klinik, Universitätsspital Zürich
(BASEC)
Scientific Information
not available
Name of the authorising ethics committee (for multicentre studies, only the lead committee)
Ethics Committee Zurich
(BASEC)
Date of authorisation
16.05.2025
(BASEC)
ICTRP Trial ID
not available
Official title (approved by ethics committee)
Safety and immunogenicity of cat-allergen intralymphatic immunotherapy: an open label Phase II study in patients with cat allergy with and without asthma (BASEC)
Academic title
not available
Public title
not available
Disease under investigation
not available
Intervention under investigation
not available
Type of trial
not available
Trial design
not available
Inclusion/Exclusion criteria
not available
not available
Primary and secondary end points
not available
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Registration date
not available
Incorporation of the first participant
not available
Secondary sponsors
not available
Additional contacts
not available
Secondary trial IDs
not available
Results-Individual Participant Data (IPD)
not available
Further information on the trial
not available
Results of the trial
Results summary
not available
Link to the results in the primary register
not available