Relevance of a High-Fiber Diet for Cancer Immunotherapy in Lung Cancer
Summary description of the study
In the present study 'Fiber-Boost', we investigate how a high-fiber diet affects the immunotherapy of advanced lung cancer and what effects it has on the gut microbiome (i.e., the bacteria in the gut) as well as the immune system. Study participants will be assigned to either a test group or a control group. Only patients in the test group will undergo a high-fiber diet. The study lasts 6 weeks per patient and will be conducted at 4 centers within Switzerland. A total of 42 patients are planned to be included in the study.
(BASEC)
Intervention under investigation
Patients in the test group receive a high-fiber diet through the intake of plant fibers with food (product 'OptiFibre' from Nestlé Health Science).
(BASEC)
Disease under investigation
Advanced Stage Lung Cancer
(BASEC)
-Age at least 18 years -Diagnosis of advanced lung carcinoma -First-line therapy with an immune checkpoint inhibitor (BASEC)
Exclusion criteria
-Previous therapy with immune checkpoint inhibitors -Taking immunosuppressive medications (BASEC)
Trial sites
Basel, Chur, St. Gallen, Winterthur
(BASEC)
Sponsor
HOCH Health Ostschweiz
(BASEC)
Contact
Contact Person Switzerland
Maximilian Bösch, Ph.D.
+41714947143
maximilian.boesch@clutterh-och.chLung Center and Medical Oncology and Hematology, HOCH Health Ostschweiz
(BASEC)
Scientific Information
not available
Name of the authorising ethics committee (for multicentre studies, only the lead committee)
Ethikkommission Ostschweiz EKOS
(BASEC)
Date of authorisation
10.04.2025
(BASEC)
ICTRP Trial ID
not available
Official title (approved by ethics committee)
Multicenter, Randomized, Controlled Trial to Study the Effects of a High-Fiber Dietary Intervention on ctDNA Clearance and the Microbial and Immunological Landscape in Patients with Advanced Non-Small Cell Lung Cancer Receiving PD-1/PD-L1-Targeted Monotherapy (Fiber-Boost) (BASEC)
Academic title
not available
Public title
not available
Disease under investigation
not available
Intervention under investigation
not available
Type of trial
not available
Trial design
not available
Inclusion/Exclusion criteria
not available
not available
Primary and secondary end points
not available
not available
Registration date
not available
Incorporation of the first participant
not available
Secondary sponsors
not available
Additional contacts
not available
Secondary trial IDs
not available
Results-Individual Participant Data (IPD)
not available
Further information on the trial
not available
Results of the trial
Results summary
not available
Link to the results in the primary register
not available