Intake of Probiotic with Streptococcus salivarius K12 Bacteria: Colonization of the Oral Cavity, Effects on Oral Flora and Oral Inflammatory Markers
Summary description of the study
Probiotics contain live microorganisms that should provide health benefits. The lozenges BIOTICS-O from Burgerstein contain live Streptococcus salivarius BLIS® K12 bacteria and are intended to optimally support the oral and throat flora. This pilot study investigates the effect of BIOTICS-O. 12 healthy participants will consume one lozenge daily for 4 weeks. Saliva and dental plaque samples will be examined before, during, and after the treatment phase. The main question is whether the probiotic bacteria Streptococcus salivarius BLIS® K12 can colonize the oral cavity and whether they can influence the composition of the oral flora. Additionally, the saliva of the participants will also be tested for inflammatory markers to measure any potential effect on the immune system. This pilot study will assess the impact of BIOTICS-O on oral health.
(BASEC)
Intervention under investigation
Dietary Supplement Burgerstein BIOTICS-O
(BASEC)
Disease under investigation
Oral Health
(BASEC)
- Healthy adults (> 18 years) - No untreated caries or active periodontal disease (BASEC)
Exclusion criteria
- Intake of anti-inflammatory medications, antimicrobial substances, and probiotics in the last 4 weeks (BASEC)
Trial sites
Zurich
(BASEC)
Sponsor
Klinik für Zahnerhaltung und Präventivzahnmedizin, Zentrum für Zahnmedizin, Zürich
(BASEC)
Contact
Contact Person Switzerland
Sybille Schwendener
+41 44 634 33 76
sybille.schwendener@clutterzzm.uzh.chUniversität Zürich Zentrum für Zahnmedizin Klinik für Zahnerhaltung und Präventivzahnmedizin
(BASEC)
Scientific Information
not available
Name of the authorising ethics committee (for multicentre studies, only the lead committee)
Ethics Committee Zurich
(BASEC)
Date of authorisation
24.04.2026
(BASEC)
ICTRP Trial ID
not available
Official title (approved by ethics committee)
Administration of oral probiotic Streptococcus salivarius K12: oral colonization, impact on oral microbiome and inflammatory markers (BASEC)
Academic title
not available
Public title
not available
Disease under investigation
not available
Intervention under investigation
not available
Type of trial
not available
Trial design
not available
Inclusion/Exclusion criteria
not available
not available
Primary and secondary end points
not available
not available
Registration date
not available
Incorporation of the first participant
not available
Secondary sponsors
not available
Additional contacts
not available
Secondary trial IDs
not available
Results-Individual Participant Data (IPD)
not available
Further information on the trial
not available
Results of the trial
Results summary
not available
Link to the results in the primary register
not available