Investigation of the Clinical Efficacy of Adjunctive Subgingival Use of Air Polishing with and without Application of Biologics in the Non-Surgical Therapy of Patients with Periodontitis Stage III/IV – A Multicenter Randomized Controlled Study
Summary description of the study
The aim of this planned study is to evaluate the clinical efficacy of the adjunctive use of air polishing in patients with generalized periodontitis stage III or IV, for whom scaling and root planning is already planned, compared to scaling and root planning (SRP) alone using ultrasonic devices and curettes, as well as the additional application of cross-linked hyaluronic acid and enamel matrix proteins.
(BASEC)
Intervention under investigation
- Therapy A: SRP
- Therapy B: SRP + Air Polishing
- Therapy C: SRP + Air Polishing + Hyaluronic Acid
- Therapy D: SRP + Air Polishing + Enamel Matrix Proteins
(BASEC)
Disease under investigation
Periodontitis Stage III/IV
(BASEC)
• Age: at least 18 years • Patients with generalized periodontitis stage III or IV • At least 18 existing teeth • With at least one single-rooted tooth in each quadrant with at least one site with probing depth of ≥ 6 mm ('Index Tooth') • Radiological evidence of periodontal bone loss of more than 33% of the root length • Planned scaling and root planning (SRP) (BASEC)
Exclusion criteria
• Subgingival root surface instrumentation in the last 12 months • Use of local or systemic antibiotics within the last 4 months • Intake of medications associated with the development of gingival overgrowth • Intake of medications that affect bone metabolism (anti-resorptives) • Systemic diseases that have known interactions with periodontal diseases or require prophylactic antibiotic shielding • Pregnancy (BASEC)
Trial sites
Zurich
(BASEC)
Sponsor
Zentrum für Zahnmedizin
(BASEC)
Contact
Contact Person Switzerland
Prof. Dr. med. dent. Patrick Schmidlin
+41 44 634 34 17
patrick.schmidlin@clutterzzm.uzh.chZentrum für Zahnmedizin Universität Zürich
(BASEC)
Scientific Information
not available
Name of the authorising ethics committee (for multicentre studies, only the lead committee)
Ethics Committee Zurich
(BASEC)
Date of authorisation
13.05.2025
(BASEC)
ICTRP Trial ID
not available
Official title (approved by ethics committee)
Investigation of the clinical efficacy of adjunctive subgingival use of airpolishing with and without application of biologics in the non-surgical treatment of patients with stage III/IV periodontitis - a multicenter randomized controlled trial (BASEC)
Academic title
not available
Public title
not available
Disease under investigation
not available
Intervention under investigation
not available
Type of trial
not available
Trial design
not available
Inclusion/Exclusion criteria
not available
not available
Primary and secondary end points
not available
not available
Registration date
not available
Incorporation of the first participant
not available
Secondary sponsors
not available
Additional contacts
not available
Secondary trial IDs
not available
Results-Individual Participant Data (IPD)
not available
Further information on the trial
not available
Results of the trial
Results summary
not available
Link to the results in the primary register
not available