Comparison of the Toxicity of a Single Session versus Multiple Radiation Therapy Sessions for the Treatment of Metastases

Summary description of the study

Since the 1990s, a radiation technique known as stereotactic body radiation therapy (SBRT) has been used for the local treatment of metastases, particularly in the brain, bones, lungs, liver, neck, lymph nodes, or other soft tissues. There are various ways to perform SBRT. In most cases, each metastasis is treated by administering a low radiation dose multiple times in succession, a technique referred to as SBRT with multiple fractions. Another technique involves administering a high radiation dose in a single session. Although this technique, known as SBRT with single fraction, may have several advantages (i.e., fewer hospital visits, less financial and logistical burden), it is still rarely used in clinical practice. In this sub-study, we investigate whether the administration of a high radiation dose in a single session (i.e., SBRT with single fraction) is as safe and effective for the treatment of oligometastases as the administration of several lower radiation doses (i.e., SBRT with multiple fractions).

(BASEC)

Intervention under investigation

We investigate whether the administration of a high radiation dose in a single session (i.e., SBRT with single fraction) is as safe and effective for the treatment of oligometastases as the administration of several lower radiation doses (i.e., SBRT with multiple fractions).

(BASEC)

Disease under investigation

oligometastatic tumor disease

(BASEC)

Sponsor

not available

Name of the authorising ethics committee (for multicentre studies, only the lead committee)

Ethics Committee Zurich

(BASEC)

Date of authorisation

14.03.2025

(BASEC)

Results of the trial