Study on the change of basal metabolic rate during fasting

Summary description of the study

During fasting, the energy expenditure of the human body is reduced. The extent of this adjustment varies significantly between different individuals. The aim of this research project is to investigate how this metabolic adjustment is regulated by the body. To this end, we will initially measure, as part of a preliminary study, how the so-called basal metabolic rate of the body responds to a short-term fast of 24 h. Those participants with a particularly pronounced reaction and those with a less pronounced reaction of the basal metabolic rate will be invited to the main study. This will be compared in a random order (24 h fasting vs. 8 h fasting) - how the basal metabolic rate of the body reacts to the reduced energy intake. - how energy expenditure increases after a test meal - what role particularly thyroid hormones play in this adjustment. Additionally, a sample of subcutaneous adipose tissue will be taken and examined to see how the regulation of metabolic processes occurs at the cellular level.

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Intervention under investigation

Fasting for 24 h compared to normal diet

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Disease under investigation

Healthy subjects

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Sponsor

ETH Zürich, Prof Dr med Jörg Goldhahn

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Name of the authorising ethics committee (for multicentre studies, only the lead committee)

Ethics Committee northwest/central Switzerland EKNZ

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Date of authorisation

12.10.2023

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Results of the trial