Plasma Oxytocin Changes in Response to Music Modified by Sound Amplification Technology Compared to Non-modified Control Music in Healthy Controls and Patients with AVP Deficiency
Summary description of the study
The aim of this scientific study is to investigate the concentration of oxytocin using music modified by sound amplification technology in healthy participants. Small previous studies have demonstrated oxytocin release in healthy individuals with this modified music. We now want to investigate whether this is reproducible.
Oxytocin is a hormone produced in the brain and released into the bloodstream by the pituitary gland. It is involved in important psychosocial aspects and has a positive influence on the mother-child relationship, as well as feelings such as love, trust, and relaxation. In some conditions, such as in patients with pituitary gland disorders, a reduced concentration of oxytocin in the blood is suspected. This could explain why patients often experience symptoms such as anxiety and depression. Music modified by sound amplification technology is a new technology that is taking its first steps in medicine. Currently, sound amplification technology is not approved as a medical intervention but has been used in various studies with healthy subjects. Some studies have shown that this modified music leads to an increase in oxytocin in healthy participants.
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Intervention under investigation
Music modified with sound amplification technology
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Disease under investigation
AVP deficiency or oxytocin deficiency
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You are between 18 and 65 years old
Healthy and not taking any medications (except hormonal contraception)
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Exclusion criteria
Pregnant or breastfeeding
Have ever suffered from a psychotic disorder (e.g., schizophrenia, bipolar disorder)
Currently being treated for a severe psychiatric disorder (e.g., severe depression)
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Trial sites
Basel
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Sponsor
Mirjam Christ-Crain
(BASEC)
Contact
Contact Person Switzerland
Andi Nikaj
0041 61 328 57 43
andi.nikaj@clutterusb.chUniversity Hospital Basel
(BASEC)
Scientific Information
not available
Name of the authorising ethics committee (for multicentre studies, only the lead committee)
Ethics Committee northwest/central Switzerland EKNZ
(BASEC)
Date of authorisation
25.11.2025
(BASEC)
ICTRP Trial ID
not available
Official title (approved by ethics committee)
Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology vs Unaugmented Control Music in Healthy Controls and Patients with AVP-Deficiency – The TechnOXY Study (BASEC)
Academic title
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Public title
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Disease under investigation
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Intervention under investigation
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Type of trial
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Trial design
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Inclusion/Exclusion criteria
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Primary and secondary end points
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Registration date
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Incorporation of the first participant
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Secondary sponsors
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Additional contacts
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Secondary trial IDs
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Results-Individual Participant Data (IPD)
not available
Further information on the trial
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Results of the trial
Results summary
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Link to the results in the primary register
not available